Doctor Sosa is a distinguished researcher with a robust publication record in various areas of medical science, as evidenced by the breadth and depth of their work. Their contributions span from fundamental research in cellular mechanisms to clinical investigations and systematic reviews, demonstrating a versatile and impactful career in medicine. This overview highlights the key areas of Doctor Sosa’s research, drawing from a selection of their published works.
Cancer Research and Aspirin’s Role
One notable area of Doctor Sosa’s research is cancer prevention and treatment. Their work, exemplified by the publication in Cancer Prevention Research, investigates the mechanism by which aspirin inhibits prostaglandin E2 production in lung adenocarcinoma cells. This research delves into the complex interactions between aspirin, platelets, and cancer cells, shedding light on potential pathways for cancer prevention through common medications. Understanding these mechanisms is crucial for developing targeted therapies and preventative strategies in lung cancer, a leading cause of cancer mortality worldwide.
Platelet Biology and Oxidative Stress
Doctor Sosa’s expertise extends to platelet biology and the impact of oxidative stress. Their research published in the Journal of Lipid Research explores how malondialdehyde, a marker of oxidative stress, modifies platelet proteins. Furthermore, the study investigates the protective role of dicarbonyl scavengers in preventing these modifications. This work is significant in understanding the role of platelets in various diseases, including cardiovascular disease and inflammation, where oxidative stress plays a critical role. By identifying mechanisms to mitigate oxidative damage to platelets, Doctor Sosa’s research contributes to potential therapeutic interventions for these conditions.
Hematology and Coagulation Disorders
Another significant aspect of Doctor Sosa’s research portfolio is in hematology, particularly in coagulation disorders. Several publications highlight their contributions to understanding and managing rare bleeding disorders. Case studies published in Haemophilia detail acquired Factor V deficiency and the development of FXIII inhibitors in patients undergoing treatment for other conditions, such as chronic hepatitis C. These publications are valuable for clinicians as they provide insights into the complexities of acquired coagulation disorders, especially in the context of underlying medical conditions and treatments. Such detailed case reports contribute to the medical community’s knowledge base for diagnosing and managing these challenging and infrequent clinical scenarios.
Neurobiology and Retinal Function
Doctor Sosa’s earlier work also explored neurobiology, focusing on retinal function and cellular signaling in the eye. Publications in Visual Neuroscience and the Journal of Neurochemistry investigated the role of metabotropic glutamate receptors (mGluR5) and calcium signaling in retinal amacrine cells. This fundamental research contributes to our understanding of neurotransmission and cellular communication within the retina, which is essential for visual processing. Insights gained from these studies can have implications for understanding and treating various retinal diseases and visual impairments.
Toxicology and Environmental Health
Beyond these core areas, Doctor Sosa’s research also touches on toxicology and environmental health, as demonstrated by a publication in the American Journal of Medicine concerning bromide toxicity from Dead Sea salt consumption. This publication highlights the importance of considering less common sources of toxicity and expands the scope of Doctor Sosa’s research interests to include environmental factors impacting health.
Obstetrics and Critical Care
Further expanding their research scope, Doctor Sosa has also contributed to the field of obstetrics and critical care with a book chapter on sickle cell disease and pregnancy. This demonstrates a commitment to addressing complex medical issues in diverse patient populations and clinical settings.
Conclusion
Doctor Sosa’s publications demonstrate a significant and diverse contribution to medical research. Their work spans from basic science investigations into cellular mechanisms to clinical case studies and reviews, reflecting a commitment to advancing medical knowledge across various disciplines. From cancer research and hematology to neurobiology and toxicology, Doctor Sosa’s publications provide valuable insights and contribute to the ongoing progress in understanding and treating human diseases. The breadth of their research underscores their expertise and dedication to the medical field, making “doctor sosa” a recognized name in medical research.
References
R. Sosa, S. Li, J.T. Molony, J. Liu, S. Stryker, AJ Collins. Use of Prophylactic Growth Factors and Antimicrobials in Elderly Patients with Cancer: A Systematic Review of the Medicare Database. Supportive Care in Cancer. 2017 Apr 29. [PMID: 28456908]
0. Boutaud, I. R. Sosa, T. Amin, G. Milne, D. Adler, H.S. Hwang, B. Crews, G.L. Milne, B.K. Harris, M.D. Hoeksema,
B.C. Knowllmann, P.E. Lammers, L.J. Marnett, P.P. Massion, J. A. Oates JA. Aspirin inhibits prostaglandin Ez production by lung adenocarcinoma cells by direct and platelet mediated interactions. Cancer Prevention Research. 2016 Nov;9(11):855-865. [PMID: 27554763].
I. Zagol-lkapite, I.R. Sosa, D. Oram, A. Judd, K. Amarnath, D. Stec, J. Oates, 0. Boutaud. Modification of platelet proteins by malondialdehyde: prevention by dicarbonyl scavengers. Journal of Lipid Research. 2015 Nov; 56(11):21960205. [PMID: 26378094].
I.R. Sosa, D. Gailani and A.T. Neff. Development of FXIII inhibitor in a patient with congenital FXIII deficiency receiving interferon and ribavarin therapy for chronic hepatitis C infection. Haemophilia: 2014 Nov;20(6): e429-32. [PMID: 25333572].
I.R. Sosa, P. Ellery, A. Mast, A.T. Neff and D. Gailani. Acquired Factor V deficiency in a patient without evidence of a classical inhibitor. Haemophilia: 2014 Jan; 20(1): e81-3. [PMID: 24118596].
B. Taylor, R.Sosa, W.M. Stone. Bromide Toxicity from Consumption of Dead Sea Salt, American Journal of Medicine. American Journal of Medicine: 2010 Mar;123(3): ell-2. [PMID: 20193810].
R. Sosa and E. Gleason. Activation of mGluRS modulates calcium currents in retinal amacrine cells1 Visual Neuroscience, 21: 807-816, 2004. [PMID:15733336]
R. Sosa, B. Hoffpauir, M. Rankin, R. Bruch and E. Gleason. Metabotropic glutamate receptor 5 and calcium signaling in retinal amacrine cells. Journal of Neurachemistry 81(5): 973-83, 2002. [PMID: 12065609].
Book Chapters
R. Sosa, and M. Udden (2017). Critical Care in Obstetrics. In M. Belfort, J. Phelan, G. Saade, M. Foley. Sickle Cell Disease and Pregnancy. (in press)
